Endor Technologies

Endor Technologies was established in 2007 as an spin-off of the “Instituto Catalán de Nanotecnología”. Over the last decade, in addition to research projects, our research has resulted in patents, doctoral thesis, publications, books, congress and international awards. Endor is a proud member of the SME programme of the European Medicine Agency and has the status of a innovative company granted by the Spanish Ministerio de Economía y Competitividad

CD44 is a key receptor to regenerate the skin

CD44

CD44 is a cell receptor involved in endogenous hyaluronic acid, collagen and elastin production. To be properly activated it’s necessary to act on several of CD44 receptors at the same time. This effect can only be achieved by using delivery system, otherwise ligands will get the cell asynchronously so the cell receptor will not be activated. The next image represent the technical strategy followed to develop the new active ingredient.

1. Radio Frequency & Nano Technology

The collection of products for radiofrequency is comprised of two serums: Celltense for body treatments and Hyalgen for facial treatments. If they are applied right before radiofrequency, they enhance the effects of the radiation. The use of Celltense and Hyalgen accelerates neocollagenesis, boosting the efficacy of the radiofrequency treatment and accelerating the appearance of visible results.

How it work?

How Radio Frequency and Nano Technology Work

Hyaluronic acid-coated gold nanoparticles have the unique ability to activate the CD44 cell receptor, whose mission is to regulate the endogenous production of hyaluronic acid and collagen. At the same time, gold nanoparticles absorb the electromagnetic radiation and use the absorbed energy to increase their temperature, boosting their efficacy. Applied on the skin prior to radiofrequency, coated nanoparticles speed up the production of collagen.

Efficacy of the active

Efficacy of the active

Biopsies were taken to demonstrate the efficacy of the active ingredient in combination with radiofrequency. The volunteer underwent one radiofrequency session per week for six weeks.

Measurements were taken one week after the last session.

Result, it was observed that in the placebo zone where only radiofrequency was applied, the collagen has diminished due to thermal damage. In the zone with Celltense + RF we found significant neocollagenesis just one week after finishing the 6-session cycle, which accelerates the appearance of visible results.

Products

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Celltense
Celltense
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Hyalgen
Hyalgen

2. The Body Collection

Clinical study results

A randomised doubled-blind clinical study has been performed with control in 23 volunteers. Each volunteer applied on one thigh with the control product (hyaluronic acid at 3% in regular form) and the treatment product (with Gold thiothylamino hyaluronic acid at 3%), twice a day during 28 days.

It has been proven clinically that the anti-cellulite effect of the hyaluronic acid is due to the conjugation of the gold nanoparticles. We measured the ecogenic density with ultrasonography. The below chart summarizes the average values obtained in the study for the treatment and control groups.

Cellulite reduction

We measured the main parameters describing the orange peel syndrome: dimple volume, area and perimeter. The average results are shown in the chart below:

Clinical study summary

Double-blinded clinical study (placebo with the same concentration -3%- of hyaluronic acid with no nanoparticle) performed with 23 volunteers during 28 days (two daily applications) resulted in the following:

31% Cellulite volume reduction on average (placebo < 1%)
22% Cellulite area reduction on average (tightening effect) (placebo < 1%)
17% Dimple diameter reduction on average (placebo < 1%)
7% Roughness reduction on average (placebo < 1%)

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Anti-Cellulite Cream
Anti-Cellulite Cream

3. The Facial Collection

The Serum and Cream help to enhance the skin’s natural ability to produce hyaluronic acid, collagen and elastin, which are the proteins giving structure to the skin. This will have a direct and important impact on skin health and conditions.

Patient benefits

  • Reduces the appearance of wrinkles.
  • Increases skin firmness.
  • Smoothes skin texture.
  • Reduces skin impurities.
  • Improves skin hydration.

Facial Product Range

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Anti-aging Nutritive Cream
Anti-aging Nutritive Cream
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Anti-aging Eye Contour
Anti-aging Eye Contour
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Anti-aging Serum
Anti-aging Serum